{"id":356,"date":"2023-06-02T10:11:00","date_gmt":"2023-06-02T10:11:00","guid":{"rendered":"https:\/\/robustcircuit.flygen.org\/?p=356"},"modified":"2024-12-20T09:04:25","modified_gmt":"2024-12-20T09:04:25","slug":"first-collaborative-paper-of-projects-p6-p7-out-in-the-journal-nature","status":"publish","type":"post","link":"https:\/\/robustcircuit.flygen.org\/?p=356","title":{"rendered":"First collaborative paper of projects P6 &#038; P7 out in the journal Nature"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06099-0\" target=\"_blank\" rel=\"noreferrer noopener\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"321\" height=\"116\" src=\"https:\/\/i0.wp.com\/robustcircuit.flygen.org\/wp-content\/uploads\/2023\/06\/image.png?resize=321%2C116&#038;ssl=1\" alt=\"\" class=\"wp-image-357\" srcset=\"https:\/\/i0.wp.com\/robustcircuit.flygen.org\/wp-content\/uploads\/2023\/06\/image.png?w=321&amp;ssl=1 321w, https:\/\/i0.wp.com\/robustcircuit.flygen.org\/wp-content\/uploads\/2023\/06\/image.png?resize=300%2C108&amp;ssl=1 300w\" sizes=\"auto, (max-width: 321px) 100vw, 321px\" \/><\/a><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">The labs of Susanne Schreiber and Carsten Duch just reported their progress in figuring out the role of noisy electrical coupling for robust flight pattern generation in Drosophila. The work was carried out by Silvan H\u00fcrkey, Nelson Niemeyer, Jan-Hendrik Schleimer and Stefanie Ryglewski in a close and RobustCircuit-initiated collaboration. <a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06099-0\" target=\"_blank\" rel=\"noreferrer noopener\">Check out the paper (open access)<\/a>.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">Gap junctions desynchronize a neural circuit to stabilize insect flight<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/\"><em>Nature<\/em><\/a> <strong>volume&nbsp;618<\/strong>,&nbsp;pages 118\u2013125 (2023)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Insect asynchronous flight is one of the most prevalent forms of animal locomotion used by more than 600,000 species. Despite profound insights into the motor patterns<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06099-0#ref-CR1\">1<\/a><\/sup>, biomechanics<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06099-0#ref-CR2\">2<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06099-0#ref-CR3\">3<\/a><\/sup> and aerodynamics underlying asynchronous flight<sup><a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06099-0#ref-CR4\">4<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41586-023-06099-0#ref-CR5\">5<\/a><\/sup>, the architecture and function of the central-pattern-generating (CPG) neural network remain unclear. Here, on the basis of an experiment\u2013theory approach including electrophysiology, optophysiology, <em>Drosophila<\/em> genetics and mathematical modelling, we identify a miniaturized circuit solution with unexpected properties. The CPG network consists of motoneurons interconnected by electrical synapses that, in contrast to doctrine, produce network activity splayed out in time instead of synchronized across neurons. Experimental and mathematical evidence support a generic mechanism for network desynchronization that relies on weak electrical synapses and specific excitability dynamics of the coupled neurons. In small networks, electrical synapses can synchronize or desynchronize network activity, depending on the neuron-intrinsic dynamics and ion channel composition. In the asynchronous flight CPG, this mechanism translates unpatterned premotor input into stereotyped neuronal firing with fixed sequences of cell activation that ensure stable wingbeat power and, as we show, is conserved across multiple species. Our findings prove a wider functional versatility of electrical synapses in the dynamic control of neural circuits and highlight the relevance of detecting electrical synapses in connectomics.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The labs of Susanne Schreiber and Carsten Duch just reported their progress in figuring out the role of noisy electrical coupling for robust flight pattern generation in Drosophila. The work&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4,1],"tags":[],"class_list":["post-356","post","type-post","status-publish","format-standard","hentry","category-news","category-publications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>First collaborative paper of projects P6 &amp; P7 out in the journal Nature - RobustCircuit<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/robustcircuit.flygen.org\/?p=356\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First collaborative paper of projects P6 &amp; P7 out in the journal Nature - RobustCircuit\" \/>\n<meta property=\"og:description\" content=\"The labs of Susanne Schreiber and Carsten Duch just reported their progress in figuring out the role of noisy electrical coupling for robust flight pattern generation in Drosophila. 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