{"id":411,"date":"2024-02-29T14:09:50","date_gmt":"2024-02-29T14:09:50","guid":{"rendered":"https:\/\/robustcircuit.flygen.org\/?p=411"},"modified":"2024-12-20T08:33:13","modified_gmt":"2024-12-20T08:33:13","slug":"new-silies-lab-p5-paper-heterogeneity-of-connecitivity-in-the-fly-visual-system","status":"publish","type":"post","link":"https:\/\/robustcircuit.flygen.org\/?p=411","title":{"rendered":"New Silies Lab (P5) Paper: Heterogeneity of synaptic connectivity in the fly visual system in Nat. Comm."},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"536\" height=\"216\" src=\"https:\/\/i0.wp.com\/robustcircuit.flygen.org\/wp-content\/uploads\/2024\/02\/nature-comm.png?resize=536%2C216&#038;ssl=1\" alt=\"\" class=\"wp-image-470\" srcset=\"https:\/\/i0.wp.com\/robustcircuit.flygen.org\/wp-content\/uploads\/2024\/02\/nature-comm.png?w=536&amp;ssl=1 536w, https:\/\/i0.wp.com\/robustcircuit.flygen.org\/wp-content\/uploads\/2024\/02\/nature-comm.png?resize=300%2C121&amp;ssl=1 300w\" sizes=\"auto, (max-width: 536px) 100vw, 536px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Wiring variability in the fly &#8211; a connectome analysis by <a href=\"https:\/\/robustcircuit.flygen.org\/?page_id=130\">RobustCircuit Team Project 5, spearheaded by Jacquline Cornea in Marion Silies&#8217; lab.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-45971-z\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Now out (open access) in Nature Communications &#8211; congrats!<\/em><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Abstract: Visual systems are homogeneous structures, where repeating columnar units retinotopically cover the visual field. Each of these columns contain many of the same neuron types that are distinguished by anatomic, genetic and \u2013 generally \u2013 by functional properties. However, there are exceptions to this rule. In the 800 columns of the Drosophila eye, there is an anatomically and genetically identifiable cell type with variable functional properties, Tm9. Since anatomical connectivity shapes functional neuronal properties, we identified the presynaptic inputs of several hundred Tm9s across both optic lobes using the full adult female fly brain (FAFB) electron microscopic dataset and FlyWire connectome. Our work shows that Tm9 has three major and many sparsely distributed inputs. This differs from the presynaptic connectivity of other Tm neurons, which have only one major, and more stereotypic inputs than Tm9. Genetic synapse labeling showed that the heterogeneous wiring exists across individuals. Together, our data argue that the visual system uses heterogeneous, distributed circuit properties to achieve robust visual processing.<\/p>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/www.nature.com\/articles\/s41467-024-45971-z\n<\/div><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Wiring variability in the fly &#8211; a connectome analysis by RobustCircuit Team Project 5, spearheaded by Jacquline Cornea in Marion Silies&#8217; lab. Now out (open access) in Nature Communications &#8211;&hellip;<\/p>\n","protected":false},"author":1,"featured_media":412,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4,1],"tags":[],"class_list":["post-411","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-publications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Silies Lab (P5) Paper: Heterogeneity of synaptic connectivity in the fly visual system in Nat. 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