{"id":453,"date":"2024-10-09T14:38:59","date_gmt":"2024-10-09T14:38:59","guid":{"rendered":"https:\/\/robustcircuit.flygen.org\/?p=453"},"modified":"2024-12-20T08:25:34","modified_gmt":"2024-12-20T08:25:34","slug":"new-paper-on-connectomic-stereotypy-wernet-lab-project-p3-in-nature","status":"publish","type":"post","link":"https:\/\/robustcircuit.flygen.org\/?p=453","title":{"rendered":"New Paper on Connectomic Stereotypy (Wernet Lab, Project P3) in Nature"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Nature. 2024 Oct;634(8032):181-190. doi: 10.1038\/s41586-024-07967-z.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"474\" height=\"131\" src=\"https:\/\/i0.wp.com\/robustcircuit.flygen.org\/wp-content\/uploads\/2024\/10\/nature.png?resize=474%2C131&#038;ssl=1\" alt=\"\" class=\"wp-image-463\" style=\"width:255px;height:auto\" srcset=\"https:\/\/i0.wp.com\/robustcircuit.flygen.org\/wp-content\/uploads\/2024\/10\/nature.png?w=474&amp;ssl=1 474w, https:\/\/i0.wp.com\/robustcircuit.flygen.org\/wp-content\/uploads\/2024\/10\/nature.png?resize=300%2C83&amp;ssl=1 300w\" sizes=\"auto, (max-width: 474px) 100vw, 474px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39358517\/\">Connectomic reconstruction predicts visual features used for navigation.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Garner D, Kind E, Lai JYH, Nern A, Zhao A, Houghton L, Sancer G, Wolff T, Rubin GM, <strong>Wernet MF<\/strong>*, Kim SS*. co-corresponding authors<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Many animals use visual information to navigate<sup>1-4<\/sup>, but how such information is encoded and integrated by the navigation system remains incompletely understood. In Drosophila melanogaster, EPG neurons in the central complex compute the heading direction<sup>5<\/sup> by integrating visual input from ER neurons<sup>6-12<\/sup>, which are part of the anterior visual pathway (AVP)<sup>10,13-16<\/sup>. Here we densely reconstruct all neurons in the AVP using electron-microscopy data<sup>17<\/sup>. The AVP comprises four neuropils, sequentially linked by three major classes of neurons: MeTu neurons<sup>10,14,15<\/sup>, which connect the medulla in the optic lobe to the small unit of the anterior optic tubercle (AOTUsu) in the central brain; TuBu neurons<sup>9,16<\/sup>, which connect the AOTUsu to the bulb neuropil; and ER neurons<sup>6-12<\/sup>, which connect the bulb to the EPG neurons. On the basis of morphologies, connectivity between neural classes and the locations of synapses, we identify distinct information channels that originate from four types of MeTu neurons, and we further divide these into ten subtypes according to the presynaptic connections in the medulla and the postsynaptic connections in the AOTUsu. Using the connectivity of the entire AVP and the dendritic fields of the MeTu neurons in the optic lobes, we infer potential visual features and the visual area from which any ER neuron receives input. We confirm some of these predictions physiologically. These results provide a strong foundation for understanding how distinct sensory features can be extracted and transformed across multiple processing stages to construct higher-order cognitive representations.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature. 2024 Oct;634(8032):181-190. doi: 10.1038\/s41586-024-07967-z. Connectomic reconstruction predicts visual features used for navigation. Garner D, Kind E, Lai JYH, Nern A, Zhao A, Houghton L, Sancer G, Wolff T, Rubin&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[4,1],"tags":[],"class_list":["post-453","post","type-post","status-publish","format-standard","hentry","category-news","category-publications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New Paper on Connectomic Stereotypy (Wernet Lab, Project P3) in Nature - RobustCircuit<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/robustcircuit.flygen.org\/?p=453\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Paper on Connectomic Stereotypy (Wernet Lab, Project P3) in Nature - RobustCircuit\" \/>\n<meta property=\"og:description\" content=\"Nature. 2024 Oct;634(8032):181-190. doi: 10.1038\/s41586-024-07967-z. Connectomic reconstruction predicts visual features used for navigation. 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